human immunodeficiency virus type 1 Tat
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Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53
Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellular genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin i...
متن کاملTranscriptional activation in vitro by the human immunodeficiency virus type 1 Tat protein: evidence for specific interaction with a coactivator(s).
The Tat protein encoded by human immunodeficiency virus type 1 is a strong transcriptional activator of gene expression from the viral long terminal repeat and is essential for virus replication. We have investigated the molecular mechanism of Tat trans-activation by using a cell-free transcription system. We find that the trans-activation domain of Tat, amino acid residues 1-48 [Tat-(1-48)], c...
متن کاملApoptosis Lymphoid, Epithelial, and Neuronal Cell Lines from Death by Human Immunodeficiency Virus Type 1 Tat Protein Protects
We report here that the tat gene product of human immunodeficiency virus type 1 was able to protect iymphoblastoid (Jurkat), epithelial (293) and neuronal (PC12) cell lines from apoptotic death induced by serum withdrawal. The rescue from apoptosis by Tat was reflected by an increased expression of Bci-2 protein in tat-positive Jurkat cells with respect to mock-transfected Jurkat cells after 3-...
متن کاملHuman immunodeficiency virus type 1 Tat activity in human neuronal cells: uptake and trans-activation.
Neurological dysfunction in AIDS occurs in the absence of productive infection of neurons, and may involve modulation of neuronal cell function by viral or cellular products released from surrounding infected cells. The human immunodeficiency virus type 1 (HIV-1) trans-activator protein Tat may be one such factor, as it can act as a neurotoxin, induces marked morphological changes in neurons an...
متن کاملInhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activators.
We examined the mechanism of Tat-mediated trans activation through competition experiments employing Tat proteins of human immunodeficiency virus type 1 (HIV-1) and equine infectious anemia virus (EIAV). EIAV Tat, as well as chimeric EIAV/HIV-1 Tat proteins, inhibited HIV-1 Tat-mediated trans activation in a cell-type-dependent fashion. Furthermore, these proteins inhibited trans activation by ...
متن کاملNMR structure of a biologically active peptide containing the RNA-binding domain of human immunodeficiency virus type 1 Tat.
The Tat protein of human immunodeficiency virus type 1 enhances transcription by binding to a specific RNA element on nascent viral transcripts. Binding is mediated by a 10-amino acid basic domain that is rich in arginines and lysines. Here we report the three-dimensional peptide backbone structure of a biologically active 25-mer peptide that contains the human immunodeficiency virus type 1 Tat...
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